International Journal of Pharmaceutics

Volume 121, Issue 1, 6 July 1995, Pages 117-121

doi:10.1016/0378-5173(95)00019-F | How to Cite or Link Using DOI

Copyright © 1995 Published by Elsevier Science B.V. Cited By in Scopus (6)

Permissions & Reprints

Note

Gliadin films. I: Preparation and in vitro evaluation as a carrier for controlled drug release

V. Stellac, a, P. Vallée a, P. Albrecht c and E. Postaire b,

a Department of Clinical Pharmacy, School of Pharmacy, University of Paris XI, rue J.B. Clément, F-92290, Châtenay-Malabry, France

b Scientific Management, Central Pharmacy for Paris Hospitals, 7 rue du Fer à Moulin, F-75005, Paris, France

c Skansen Pharma SA, 1 avenue du Grand Chêne, F-34270, Saint-Mathieu de Treviers, France

Received 16 September 1994; revised 4 January 1995; accepted 18 January 1995. ; Available online 22 November 1999.

Abstract

A method for the preparation of soft capsules (Gl.C) and chewable gums (GCG) of the hydrophobic wheat protein, crude gliadin, is reported. Gliadin films were found to be more hydrophilic than comparable gelatin films. The release of paracetamol was significantly sustained, indicating drug delivery. Drug release profiles in 0.1 M hydrochloric acid media consisted of three regions for Gl.C: these were an initial latency period, followed by a low release region and essentially constant rate; and one region for GCG with very slow release of paracetamol. A mechanism of drug release is proposed involving hydrophobic interaction between gliadin and non-polar ligands. These results are discussed and based on this study, gliadin appears to be a highly promising, low-cost, bioacceptable protein for the manufacture of drug formulations with a very interesting controlled released potency.

Author Keywords: Gliadin; Capsule; Chewable gum; Paracetamol; Controlled release

Article Outline

• References

Corresponding author. Tel. (33) 1 46 69 15 17; Fax (33) 1 46 69 13 01.

International Journal of Pharmaceutics